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The Significance of Urinary RBP and KIM-1 Determination in Cisplatin – Induced Acute Kidney Injury

Received: 6 May 2021     Accepted: 24 May 2021     Published: 25 June 2021
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Abstract

Objective: Cisplatin is one of the most commonly used and most effective chemotherapy drugs in clinical treatment of solid tumors, because of its strong anti-cancer effect, no cross resistance with other cancer drugs, but cisplatin is one of the significant renal toxicity drugs either, which greatly limits its clinical application. The traditional diagnostic methods for AKI are to measure Scr and changes in urine volume, but these indicators are affected by non-renal factors and cannot reflect renal function in an early and timely manner, which delays the optimal early treatment time for AKI. To discuss the clinical value of detecting urinary retinol binding protein (RBP) and kidney injury molecule 1 (KIM-1) in early diagonsis of cisplatin-induced acute kidney injury. Methods: 48 rats were randomly divided into the cisplatin group (CP group, 42 rats) and the control group (NS group, 6 rats). The urinary RBP and KIM-1, renal pathological changes were observed at each injection time points. Results: Urinary KIM-1 it significantly increased at 12h point (P<0.05), which was higher obviously than NS group. Urinary RBP it significantly elevated at 6h point (P<0.05). It has correlation with Scr. Conclusion: In cisplatin-induced acute kidney injury, urinary RBP and KIM-1 increased obviously earlier than serum creatinine, they were early sensitive markers.

Published in Science Journal of Clinical Medicine (Volume 10, Issue 2)
DOI 10.11648/j.sjcm.20211002.16
Page(s) 47-51
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2021. Published by Science Publishing Group

Keywords

Cisplatin, Acute Kidney Injury, Urinary Retinol Binding Protein, Kidney Injury Molecule 1

References
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Cite This Article
  • APA Style

    Yang Haoqiang, Meng Xiaoyan, Huang Xiangyang, Tan Hechang, Zhang Min, et al. (2021). The Significance of Urinary RBP and KIM-1 Determination in Cisplatin – Induced Acute Kidney Injury. Science Journal of Clinical Medicine, 10(2), 47-51. https://doi.org/10.11648/j.sjcm.20211002.16

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    ACS Style

    Yang Haoqiang; Meng Xiaoyan; Huang Xiangyang; Tan Hechang; Zhang Min, et al. The Significance of Urinary RBP and KIM-1 Determination in Cisplatin – Induced Acute Kidney Injury. Sci. J. Clin. Med. 2021, 10(2), 47-51. doi: 10.11648/j.sjcm.20211002.16

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    AMA Style

    Yang Haoqiang, Meng Xiaoyan, Huang Xiangyang, Tan Hechang, Zhang Min, et al. The Significance of Urinary RBP and KIM-1 Determination in Cisplatin – Induced Acute Kidney Injury. Sci J Clin Med. 2021;10(2):47-51. doi: 10.11648/j.sjcm.20211002.16

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  • @article{10.11648/j.sjcm.20211002.16,
      author = {Yang Haoqiang and Meng Xiaoyan and Huang Xiangyang and Tan Hechang and Zhang Min and Shu Tingting},
      title = {The Significance of Urinary RBP and KIM-1 Determination in Cisplatin – Induced Acute Kidney Injury},
      journal = {Science Journal of Clinical Medicine},
      volume = {10},
      number = {2},
      pages = {47-51},
      doi = {10.11648/j.sjcm.20211002.16},
      url = {https://doi.org/10.11648/j.sjcm.20211002.16},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.sjcm.20211002.16},
      abstract = {Objective: Cisplatin is one of the most commonly used and most effective chemotherapy drugs in clinical treatment of solid tumors, because of its strong anti-cancer effect, no cross resistance with other cancer drugs, but cisplatin is one of the significant renal toxicity drugs either, which greatly limits its clinical application. The traditional diagnostic methods for AKI are to measure Scr and changes in urine volume, but these indicators are affected by non-renal factors and cannot reflect renal function in an early and timely manner, which delays the optimal early treatment time for AKI. To discuss the clinical value of detecting urinary retinol binding protein (RBP) and kidney injury molecule 1 (KIM-1) in early diagonsis of cisplatin-induced acute kidney injury. Methods: 48 rats were randomly divided into the cisplatin group (CP group, 42 rats) and the control group (NS group, 6 rats). The urinary RBP and KIM-1, renal pathological changes were observed at each injection time points. Results: Urinary KIM-1 it significantly increased at 12h point (PConclusion: In cisplatin-induced acute kidney injury, urinary RBP and KIM-1 increased obviously earlier than serum creatinine, they were early sensitive markers.},
     year = {2021}
    }
    

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  • TY  - JOUR
    T1  - The Significance of Urinary RBP and KIM-1 Determination in Cisplatin – Induced Acute Kidney Injury
    AU  - Yang Haoqiang
    AU  - Meng Xiaoyan
    AU  - Huang Xiangyang
    AU  - Tan Hechang
    AU  - Zhang Min
    AU  - Shu Tingting
    Y1  - 2021/06/25
    PY  - 2021
    N1  - https://doi.org/10.11648/j.sjcm.20211002.16
    DO  - 10.11648/j.sjcm.20211002.16
    T2  - Science Journal of Clinical Medicine
    JF  - Science Journal of Clinical Medicine
    JO  - Science Journal of Clinical Medicine
    SP  - 47
    EP  - 51
    PB  - Science Publishing Group
    SN  - 2327-2732
    UR  - https://doi.org/10.11648/j.sjcm.20211002.16
    AB  - Objective: Cisplatin is one of the most commonly used and most effective chemotherapy drugs in clinical treatment of solid tumors, because of its strong anti-cancer effect, no cross resistance with other cancer drugs, but cisplatin is one of the significant renal toxicity drugs either, which greatly limits its clinical application. The traditional diagnostic methods for AKI are to measure Scr and changes in urine volume, but these indicators are affected by non-renal factors and cannot reflect renal function in an early and timely manner, which delays the optimal early treatment time for AKI. To discuss the clinical value of detecting urinary retinol binding protein (RBP) and kidney injury molecule 1 (KIM-1) in early diagonsis of cisplatin-induced acute kidney injury. Methods: 48 rats were randomly divided into the cisplatin group (CP group, 42 rats) and the control group (NS group, 6 rats). The urinary RBP and KIM-1, renal pathological changes were observed at each injection time points. Results: Urinary KIM-1 it significantly increased at 12h point (PConclusion: In cisplatin-induced acute kidney injury, urinary RBP and KIM-1 increased obviously earlier than serum creatinine, they were early sensitive markers.
    VL  - 10
    IS  - 2
    ER  - 

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Author Information
  • Department of Nephrology, Liuzhou Worker's Hospital, Liuzhou City, China

  • Department of Nephrology, Liuzhou Worker's Hospital, Liuzhou City, China

  • Department of Nephrology, Liuzhou Worker's Hospital, Liuzhou City, China

  • Department of Nephrology, Liuzhou Worker's Hospital, Liuzhou City, China

  • Department of Nephrology, Liuzhou Worker's Hospital, Liuzhou City, China

  • Department of Nephrology, Liuzhou Worker's Hospital, Liuzhou City, China

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